Predictors of castration-resistant prostate cancer after dose-escalated external beam radiotherapy.

ABSTRACT:

Background

Castration-resistant prostate cancer (CRPC) is a near uniformly fatal form of prostate cancer; however, information on time to development and predictors for progression to CRPC is limited. We report a detailed longitudinal study for development of CRPC in men initially treated with external beam radiotherapy (EBRT).

Methods

During 1991-2008, 2,478 patients with clinically localized prostate cancer were treated with dose-escalated EBRT at a single institution. The primary objective was to determine predictors of CRPC among men who failed definitive EBRT and progressed to salvage androgen-deprivation therapy (ADT). CRPC was defined as castrate levels of testosterone (<50 ng/dl) with progressive biochemical or radiographic disease.

Results

For the entire coho

SUBMITTER: Spratt DE 

PROVIDER: S-EPMC5522730 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature