Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice.

ABSTRACT: Sucralose is the most widely used artificial sweetener, and its health effects have been highly debated over the years. In particular, previous studies have shown that sucralose consumption can alter the gut microbiota. The gut microbiome plays a key role in processes related to host health, such as food digestion and fermentation, immune cell development, and enteric nervous system regulation. Inflammation is one of the most common effects associated with gut microbiome dysbiosis, which has been linked to a series of human diseases, such as diabetes and obesity. The aim of this study was to investigate the structural and functional effects of sucralose on the gut microbiota and associated inflammation in the host. In this study, C57BL/6 male mice received sucralose in their drinking water

SUBMITTER: Bian X 

PROVIDER: S-EPMC5522834 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature