Tetracycline Resistance Genes Identified from Distinct Soil Environments in China by Functional Metagenomics.

ABSTRACT: Soil microbiota represents one of the ancient evolutionary origins of antibiotic resistance and has been increasingly recognized as a potentially vast unstudied reservoir of resistance genes with possibilities to exchange with pathogens. Tetracycline resistance is one of the most abundant antibiotic resistances that may transfer among clinical and commensal microorganisms. To investigate tetracycline resistance genes from soil bacteria in different habitats, we performed functional analysis of three metagenomic libraries derived from soil samples collected from Yunnan, Sichuan, and Tibet, respectively, in China. We found efflux transporter genes form all the libraries, including 21 major facilitator superfamily efflux pump genes and one multidrug and toxic compound extrusion (MATE) transpo

SUBMITTER: Wang S 

PROVIDER: S-EPMC5522880 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature