Variation in serum prostate-specific antigen levels in men with prostate cancer managed with active surveillance.

ABSTRACT:

Objective

To describe fluctuations in prostate-specific antigen (PSA) levels in men managed with active surveillance (AS) to determine if a single PSA increase is a consistent measure to use to trigger intervention.

Patients and methods

We evaluated data on 541 patients undergoing AS between 1995 and 2011. PSA variation was described by studying the Kaplan-Meier probability of patients' PSA levels reaching 4 or 7 ng/mL, falling below those thresholds, and then rising to those thresholds again. We also examined PSA variation by calculating the Kaplan-Meier probability of a PSA change followed by an equal or greater change in the opposite direction.

Results

We analysed data on 541 patients undergoing AS with a median (interquartile range [IQR]) of 8 (6-12) PSA measureme

SUBMITTER: Ehdaie B 

PROVIDER: S-EPMC5523832 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature