Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition.

ABSTRACT:

Background

CAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile.

Objectives

This observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden evaluated with PIB-PET, and detailed cognition measures.

Methods

FINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous national surveys (mean age 52.4 years). In connection to baseline FINGER visit (on average 17.6 years later, mean age 70.1 years), 132 participants underwent MRI scans, and 48 underwent PIB-PET scans. All 1,260 participants were cognitively assessed (Neuropsychological Test Battery, NTB). Neuroimaging assessments included brain corti

SUBMITTER: Stephen R 

PROVIDER: S-EPMC5523839 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature