The association of lipoprotein(a) with incident heart failure hospitalization: Atherosclerosis Risk in Communities study.

ABSTRACT:

Background and aims

Lipoprotein(a) [Lp(a)] is a proatherogenic lipoprotein associated with coronary heart disease, ischemic stroke, and more recently aortic stenosis and heart failure (HF). We examined the association of Lp(a) levels with incident HF hospitalization in the Atherosclerosis Risk in Communities (ARIC) study. We also assessed the relationship between Lp(a) levels and arterial stiffness as a potential mechanism for development of HF.

Methods

Lp(a) was measured in 14,154 ARIC participants without prevalent HF at ARIC visit 1 (1987-1989). The association of Lp(a) quintiles with incident HF hospitalization was assessed using Cox proportional-hazards models. Arterial stiffness parameters were stratified based on Lp(a) quintiles, and p-trend was calculated across orde

SUBMITTER: Agarwala A 

PROVIDER: S-EPMC5523851 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature