Imaging biomarkers in acute ischemic stroke trials: a systematic review.

ABSTRACT:

Background and purpose

Imaging biomarkers are increasingly used to provide a better understanding of the pathophysiology of acute ischemic stroke. However, this approach of routinely using imaging biomarkers to inform treatment decisions has yet to be translated into successful randomized trials. The aim of this study was to systematically review the use of imaging biomarkers in randomized controlled trials in patients with acute ischemic stroke, exploring the purposes for which the imaging biomarkers were used.

Materials and methods

We performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. Data bases searched included MEDLINE, EMBASE,

SUBMITTER: Harston GW 

PROVIDER: S-EPMC5524169 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature