Quantification of amide proton transfer effect pre- and post-gadolinium contrast agent administration.

ABSTRACT:

Purpose

To compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish to what extent Gd alters quantification of the APT effect.

Materials and methods

Four patients with internal carotid stenosis were recruited. APT imaging was acquired pre- and post-contrast in two sessions (before and after surgery) to assess the extent of relaxation time, T1 , change on APT effect calculated using magnetization transfer ratio asymmetry analysis at offsets of ±3.5 ppm relative to water resonance. Statistical and modeling evaluations were performed on the pre- and post-contrast APT effect to study the sensitivity to contrast administration.

Results

Before surgery, the post-contrast T1 was estimate

SUBMITTER: Tee YK 

PROVIDER: S-EPMC5524170 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature