The second window ICG technique demonstrates a broad plateau period for near infrared fluorescence tumor contrast in glioblastoma.

ABSTRACT:

Introduction

Fluorescence-guided surgery has emerged as a powerful tool to detect, localize and resect tumors in the operative setting. Our laboratory has pioneered a novel way to administer an FDA-approved near-infrared (NIR) contrast agent to help surgeons with this task. This technique, coined Second Window ICG, exploits the natural permeability of tumor vasculature and its poor clearance to deliver high doses of indocyanine green (ICG) to tumors. This technique differs substantially from established ICG video angiography techniques that visualize ICG within minutes of injection. We hypothesized that Second Window ICG can provide NIR optical contrast with good signal characteristics in intracranial brain tumors over a longer period of time than previously appreciated with ICG vi

SUBMITTER: Zeh R 

PROVIDER: S-EPMC5524327 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature