Exploring the cross talk between ER stress and inflammation in age-related macular degeneration.

ABSTRACT: Increasing evidence demonstrates that inflammation and endoplasmic reticulum (ER) stress is implicated in the development and progression of age-related macular degeneration (AMD), a multifactorial neurodegenerative disease. However the cross talk between these cellular mechanisms has not been clearly and fully understood. The present study investigates a possible intersection between ER stress and inflammation in AMD. In this study, we recruited two collections of involved protein markers to retrieve their interaction information from IMEx-curated databases, which are the most well- known protein-protein interaction collections, allowing us to design an intersection network for AMD that is unprecedented. In order to find expression activated subnetworks, we utilized AMD expression profile

SUBMITTER: Kheitan S 

PROVIDER: S-EPMC5524348 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature