Variants of ACAN are associated with severity of lumbar disc herniation in patients with chronic low back pain.

ABSTRACT:

Introduction

Disc herniation is a complex spinal disorder associated with disability and high healthcare cost. Lumbar disc herniation is strongly associated with disc degeneration. Candidate genes of the aggrecan metabolic pathway may associate with the severity of lumbar disc herniation.

Objectives

This study evaluated the association of single nucleotide variants (SNVs) of the candidate genes of the aggrecan metabolic pathway with the severity of lumbar disc herniation in patients with chronic mechanical low back pain. In addition, we assessed the in-silico functional analysis of the significant SNVs and association of their haplotypes with the severity of lumbar disc herniation.

Methods

A descriptive cross sectional study was carried out on 106 patients. Severity o

SUBMITTER: Perera RS 

PROVIDER: S-EPMC5524386 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature