Postoperative atrial fibrillation: The role of the inflammatory response.

ABSTRACT:

Objective

Abnormal atrial conduction has been shown to be a substrate for postoperative atrial fibrillation (POAF). This study aimed to determine the relationship between the location of the atrial reentry responsible for POAF, and degree of atrial inflammation.

Methods

Normal mongrel dogs (n = 18) were divided into 3 groups: anesthesia alone (anesthesia), lateral right atriotomy (atriotomy), and lateral right atriotomy with anti-inflammatory therapy (steroid). Conduction properties of the right and left atria (RA and LA) were examined 3 days postoperatively by mapping. Activation was observed during burst pacing-induced AF. The RA and LA myeloperoxidase activity was measured to quantitate the degree of inflammation.

Results

Sustained AF (>2 minutes) was induced in 5

SUBMITTER: Ishii Y 

PROVIDER: S-EPMC5524456 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature