Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives.

ABSTRACT: Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance and the propensity for locoregional recurrence. Countering this, it demands a significant effort from both basic and clinical scientists in the search for more effective targeted therapies. Recent genomewide studies have provided valuable insights into the genetic basis of HNSCC, uncovering potential new therapeutic opportunities. In addition, several studies have elucidated how in

SUBMITTER: Ausoni S 

PROVIDER: S-EPMC5524458 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature