A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci.

ABSTRACT:

Background

Genome-wide association studies (GWAS) in European populations have identified genetic risk variants associated with multiple myeloma.

Methods

We performed association testing of common variation in eight regions in 1,318 patients with multiple myeloma and 1,480 controls of European ancestry and 1,305 patients with multiple myeloma and 7,078 controls of African ancestry and conducted a meta-analysis to localize the signals, with epigenetic annotation used to predict functionality.

Results

We found that variants in 7p15.3, 17p11.2, 22q13.1 were statistically significantly (P < 0.05) associated with multiple myeloma risk in persons of African ancestry and persons of European ancestry, and the variant in 3p22.1 was associated in European ancestry only. In a co

SUBMITTER: Rand KA 

PROVIDER: S-EPMC5524541 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature