MS-READ: Quantitative measurement of amino acid incorporation.

ABSTRACT: Ribosomal protein synthesis results in the genetically programmed incorporation of amino acids into a growing polypeptide chain. Faithful amino acid incorporation that accurately reflects the genetic code is critical to the structure and function of proteins as well as overall proteome integrity. Errors in protein synthesis are generally detrimental to cellular processes yet emerging evidence suggest that proteome diversity generated through mistranslation may be beneficial under certain conditions. Cumulative translational error rates have been determined at the organismal level, however codon specific error rates and the spectrum of misincorporation errors from system to system remain largely unexplored. In particular, until recently technical challenges have limited the ability to detec

SUBMITTER: Mohler K 

PROVIDER: S-EPMC5524608 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature