Sustained efficacy of closed loop electrical stimulation for long-term treatment of absence epilepsy in rats.

ABSTRACT: Closed-loop brain stimulation is a promising alternative to treat drug-resistant epilepsies. In contrast to optogenetic interventions, transcranial electrical stimulation (TES) does not require cellular modification of neurons to be effective, and it is less invasive compared to deep brain stimulation. Furthermore, on-demand TES of targeted brain regions allows the potential for normal function of these networks during interictal periods, a possibility that is eliminated by resective surgical treatment approaches. To further explore the translation of closed-loop TES for treatment of epilepsy, we show here for the first time that unsupervised closed-loop TES in rats can consistently interrupt seizures for 6 weeks and has the potential to control seizure activity up to 4 months (longest per

SUBMITTER: Kozak G 

PROVIDER: S-EPMC5524708 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature