Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.

ABSTRACT: Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated following high-fat diet, but its role in obesity is unknown. Eight-week old wild-type (WT) and Timp4-knockout (Timp4 ^-/-) mice received chow or high fat diet (HFD) for twelve weeks. Timp4 ^-/- mice exhibited a higher food intake but lower body fat gain. Adipose tissue of Timp4 ^-/- -HFD mice showed reduced hypertrophy and fibrosis compared to WT-HFD mice. Timp4 ^-/- -HFD mice were also protected from HFD-induced liver and skeletal muscle triglyceride accumulation and dyslipidemia. Timp4 ^-/--HFD mice exhibited re

SUBMITTER: Sakamuri SSVP 

PROVIDER: S-EPMC5524827 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature