Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α.

ABSTRACT: Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested whether myricetin, a natural flavonol with diverse biological activities, may impact mitochondrial function and longevity. The mice were orally administered myricetin (50 mg/kg/day) for 3 weeks. Myricetin significantly potentiated aerobic capacity in mice, as evidenced by their increased running time and distance. The elevated mitochondrial function was associated with induction of genes for oxidative phosphorylation and mitochondrial biogenesis in metabolically active tissues. Importantly, myricetin treatment led to decreased PGC-1α acetylation through S

SUBMITTER: Jung HY 

PROVIDER: S-EPMC5524912 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature