Untangling the model muddle: Empirical tumour growth in Tasmanian devil facial tumour disease.

ABSTRACT: A pressing and unresolved topic in cancer research is how tumours grow in the absence of treatment. Despite advances in cancer biology, therapeutic and diagnostic technologies, there is limited knowledge regarding the fundamental growth and developmental patterns in solid tumours. In this ten year study, we estimated growth curves in Tasmanian devil facial tumours, a clonal transmissible cancer, in males and females with two different karyotypes (diploid, tetraploid) and facial locations (mucosal, dermal), using established differential equation models and model selection. Logistic growth was the most parsimonious model for diploid, tetraploid and mucosal tumours, with less model certainty for dermal tumours. Estimates of daily proportional tumour growth rate per day (95% Bayesian CIs) var

SUBMITTER: Hamede RK 

PROVIDER: S-EPMC5524923 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature