Niosomes: A Strategy toward Prevention of Clinically Significant Drug Incompatibilities.

ABSTRACT: Drug incompatibilities are considered as one of the most critical problems in intensive care units. In the current study, the ability of nanomaterials to prevent drug incompatibilities in clinical settings has been investigated. As a proof-of-concept, the ability of niosomes to prevent physical and chemical incompatibilities that occur upon mixing acyclovir and vancomycin during management of acute meningitis has been explored. Nanosized spherical particles loaded separately with either vancomycin or acyclovir, with high entrapment efficiency (ca. 46-56%), could be prepared, and sustained release of their entrapped cargoes have been demonstrated over time. We have shown that precipitation, degradation and loss of biological activity of drugs occurred upon mixing solutions of the free drugs

SUBMITTER: Mohamed HB 

PROVIDER: S-EPMC5524940 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature