The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis.

ABSTRACT: Embryonic development is an exceptionally dynamic process, requiring a provisional extracellular matrix that is amenable to rapid remodeling, and proteolytic or non-proteolytic mechanisms that can remodel the major components of this matrix. Versican is a chondroitin-sulfate proteoglycan that forms highly hydrated complexes with hyaluronan and is widely distributed in the provisional matrix of mammalian embryos. It has been extensively studied in the context of cardiovascular morphogenesis, neural crest cell migration and skeletal development. Analysis of Vcan transgenic mice has established the requirement for versican in cardiac development and its role in skeletogenesis. The ADAMTS family includes several versican-degrading proteases that are active during remodeling of the embryonic pr

SUBMITTER: Nandadasa S 

PROVIDER: S-EPMC5525047 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature