Bacterial tail anchors can target to the mitochondrial outer membrane.

ABSTRACT:

Background

During the generation and evolution of the eukaryotic cell, a proteobacterial endosymbiont was re-fashioned into the mitochondrion, an organelle that appears to have been present in the ancestor of all present-day eukaryotes. Mitochondria harbor proteomes derived from coding information located both inside and outside the organelle, and the rate-limiting step toward the formation of eukaryotic cells may have been development of an import apparatus allowing protein entry to mitochondria. Currently, a widely conserved translocon allows proteins to pass from the cytosol into mitochondria, but how proteins encoded outside of mitochondria were first directed to these organelles at the dawn of eukaryogenesis is not clear. Because several proteins targeted by a carboxyl-termina

SUBMITTER: Lutfullahoglu-Bal G 

PROVIDER: S-EPMC5525287 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature