Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed the cancer preventive and therapeutic effects of metformin, one of the most widely prescribed medications for type 2 diabetes mellitus. However, its role in pancreatic cancer is not fully elucidated. Herein, we aimed to further study the preventive and therapeutic effects of metformin in genetically engineered mouse models of pancreatic cancer.

Methods

LSL-Kras^G12D/+; Pdx1-Cre (KC) mouse model was established to investigate the effect of metformin in pancreatic tumorigenesis suppression; LSL-Kras^G12D/+; Trp53^fl/+; Pdx1-Cre (KPC) mouse mo

SUBMITTER: Chen K 

PROVIDER: S-EPMC5525317 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature