Integration of Brain and Skull in Prenatal Mouse Models of Apert and Crouzon Syndromes.

ABSTRACT: The brain and skull represent a complex arrangement of integrated anatomical structures composed of various cell and tissue types that maintain structural and functional association throughout development. Morphological integration, a concept developed in vertebrate morphology and evolutionary biology, describes the coordinated variation of functionally and developmentally related traits of organisms. Syndromic craniosynostosis is characterized by distinctive changes in skull morphology and perceptible, though less well studied, changes in brain structure and morphology. Using mouse models for craniosynostosis conditions, our group has precisely defined how unique craniosynostosis causing mutations in fibroblast growth factor receptors affect brain and skull morphology and dysgenesi

SUBMITTER: Motch Perrine SM 

PROVIDER: S-EPMC5525342 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature