Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure.

ABSTRACT:

Background

Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based on a-priori knowledge of potentially relevant biological pathways, such as glutathione S-transferases and ADAM33. By using a hypothesis-free approach, we aimed to identify novel susceptibility loci, and additionally explored biological pathways potentially underlying this susceptibility to impaired lung function in the context of ETS exposure.

Methods

Genome-wide interactions of single nucleotide polymorphism (SNP) by ETS exposure (0 versus ≥1 h/day) in relation to the level of forced expiratory volume in one second (FEV₁) were investigated in 10,817 subjects from the

SUBMITTER: de Jong K 

PROVIDER: S-EPMC5525356 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature