Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis.

ABSTRACT:

Background

As a novel biomarker of inflammation, procalcitonin (PCT) has proven useful to guide antibiotic therapy in intensive care unit (ICU). However, there are controversial on mortality. The aim of this study was to evaluate the utility of PCT-guided antibiotic therapy in critically ill adults and determine whether studies are sufficient.

Methods

A systematic search in PubMed, Embase and Cochrane was performed. We included only randomized controlled trials which compared the safety and efficacy between PCT-guided or standard antibiotic therapy groups in ICU adults. Trial sequential analysis and GARDE approach were performed.

Results

Fifteen studies met our criteria for inclusion finally, with a cumulative number of 5486 ICU patients. There was no difference in 28

SUBMITTER: Zhang T 

PROVIDER: S-EPMC5525369 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature