Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals.

ABSTRACT:

Background

The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG).

Results

Our analysis consisted of a discovery phase using a merged dataset of five different cohorts (n = 12,853 to n = 16,849 depending on lipid phenotype) and a replication phase with ten independent cohorts totaling up to 36,938 additional samples. Filters are often applied before interaction testing to correct for the burden of testing all pairwise interactions. We used two different filters: 1. A filte

SUBMITTER: Holzinger ER 

PROVIDER: S-EPMC5525436 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature