Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study.

ABSTRACT:

Background

Acute liver failure (ALF) is a rare syndrome of severe, rapid-onset hepatic dysfunction-without prior advanced liver disease-that is associated with high morbidity and mortality. Intensive care and liver transplantation provide support and rescue, respectively.

Objective

To determine whether changes in causes, disease severity, treatment, or 21-day outcomes have occurred in recent years among adult patients with ALF referred to U.S. tertiary care centers.

Design

Prospective observational cohort study. (ClinicalTrials .gov: NCT00518440).

Setting

31 liver disease and transplant centers in the United States.

Patients

Consecutively enrolled patients-without prior advanced liver disease-with ALF (n = 2070).

Measurements

Clinical features, tr

SUBMITTER: Reuben A 

PROVIDER: S-EPMC5526039 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature