Block copolymer conjugated Au-coated Fe₃O₄ nanoparticles as vectors for enhancing colloidal stability and cellular uptake.

ABSTRACT:

Background

Polymer surface-modified inorganic nanoparticles (NPs) provide a multifunctional platform for assisting gene delivery. Rational structure design for enhancing colloidal stability and cellular uptake is an important strategy in the development of safe and highly efficient gene vectors.

Results

Heterogeneous Au-coated Fe₃O₄ (Fe₃O₄@Au) NPs capped by polyethylene glycol-b-poly1-(3-aminopropyl)-3-(2-methacryloyloxy propylimidazolium bromine) (PEG-b-PAMPImB-Fe₃O₄@Au) were prepared for DNA loading and magnetofection assays. The Au outer shell of the NPs is an effective platform for maintaining the superparamagnetism of Fe₃O₄ and for PEG-b-PAMPImB binding via Au-S covalent bonds. By fo

SUBMITTER: Li J 

PROVIDER: S-EPMC5526242 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature