Association between serotonin transporter gene polymorphisms and increased suicidal risk among HIV positive patients in Uganda.

ABSTRACT:

Background

Persons living with HIV/AIDS (PLWHA) are at an increased risk of suicide. Increased suicidal risk is a predictor of future attempted and completed suicides and has been associated with poor quality of life and poor adherence with antiretroviral therapy. Clinical risk factors have low predictive value for suicide, hence the interest in potential neurobiological correlates and specific heritable markers of suicide vulnerability. The serotonin transporter gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected study populations and its variations may provide a platform for identifying genetic risk for suicidality among PLWHA. The present cross-sectional study aimed at identifying two common genetic variants of the serotonin transp

SUBMITTER: Kalungi A 

PROVIDER: S-EPMC5526289 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature