JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

ABSTRACT: Tissue engineered scaffolds have emerged as a promising solution for heart valve replacement because of their potential for regeneration. However, traditional heart valve tissue engineering has relied on resource-intensive, cell-based manufacturing, which increases cost and hinders clinical translation. To overcome these limitations, in situ tissue engineering approaches aim to develop scaffold materials and manufacturing processes that elicit endogenous tissue remodeling and repair. Yet despite recent advances in synthetic materials manufacturing, there remains a lack of cell-free, automated approaches for rapidly producing biomimetic heart valve scaffolds. Here, we designed a jet spinning process for the rapid and automated fabrication of fibrous heart valve scaffolds. The composition, m

SUBMITTER: Capulli AK 

PROVIDER: S-EPMC5526340 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature