Biomechanical CT metrics are associated with patient outcomes in COPD.

ABSTRACT:

Background

Traditional metrics of lung disease such as those derived from spirometry and static single-volume CT images are used to explain respiratory morbidity in patients with COPD, but are insufficient. We hypothesised that the mean Jacobian determinant, a measure of local lung expansion and contraction with respiration, would contribute independently to clinically relevant functional outcomes.

Methods

We applied image registration techniques to paired inspiratory-expiratory CT scans and derived the Jacobian determinant of the deformation field between the two lung volumes to map local volume change with respiration. We analysed 490 participants with COPD with multivariable regression models to assess strengths of association between traditional CT metrics of disease and

SUBMITTER: Bodduluri S 

PROVIDER: S-EPMC5526353 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature