Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance.

ABSTRACT:

Introduction

Prolonged fasting in northern elephant seals (NES) is characterized by a reliance on lipid metabolism, conservation of protein, and reduced plasma insulin. During early fasting, glucose infusion previously reduced plasma free fatty acids (FFA); however, during late-fasting, it induced an atypical elevation in FFA despite comparable increases in insulin during both periods suggestive of a dynamic shift in tissue responsiveness to glucose-stimulated insulin secretion.

Objective

To better assess the contribution of insulin to this fasting-associated shift in substrate metabolism.

Methods

We compared the responses of plasma metabolites (amino acids (AA), FFA, endocannabinoids (EC), and primary carbon metabolites (PCM)) to an insulin infusion (65 mU/kg) in ear

SUBMITTER: Olmstead KI 

PROVIDER: S-EPMC5526460 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature