Clinical and parasitological factors in parasite persistence after treatment and clinical cure of cutaneous leishmaniasis.

ABSTRACT:

Background

The determinants of parasite persistence or elimination after treatment and clinical resolution of cutaneous leishmaniasis (CL) are unknown. We investigated clinical and parasitological parameters associated with the presence and viability of Leishmania after treatment and resolution of CL caused by L. Viannia.

Methods

Seventy patients who were treated with meglumine antimoniate (n = 38) or miltefosine (n = 32) and cured, were included in this study. Leishmania persistence and viability were determined by detection of kDNA and 7SLRNA transcripts, respectively, before, at the end of treatment (EoT), and 13 weeks after initiation of treatment in lesions and swabs of nasal and tonsillar mucosa.

Results

Sixty percent of patients (42/70) had evidence of Leishman

SUBMITTER: Martinez-Valencia AJ 

PROVIDER: S-EPMC5526576 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature