Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy.

ABSTRACT:

Purpose

Fractional exhaled nitric oxide (FeNO) has emerged as an important biomarker in asthma. Increasing evidence points to atopy as a confounding factor in the interpretation of elevated FeNO. We conducted a longitudinal study to understand the clinical significance of FeNO as an inflammatory biomarker.

Methods

We identified 19 children aged 13-15 years at baseline with a significant elevation in FeNO ≥ 80 parts per billion (ppb) and randomly selected a group of children of similar age with a moderate elevation (40-79 ppb) and normal-to-low FeNO (<40 ppb). Between November 2010 and July 2011, three additional study visits were conducted.

Results

Ninety-three children participated in the study. There were 16, 24, and 53 participants in the high, mid, and low FeNO gr

SUBMITTER: Elmasri M 

PROVIDER: S-EPMC5526602 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature