Sleep Deprivation Disrupts Recall of Conditioned Fear Extinction.

ABSTRACT:

Background

Learned fear is crucial in the development and maintenance of posttraumatic stress disorder (PTSD) and other anxiety disorders, and extinction of learned fear is necessary for response to exposure-based treatments. In humans, research suggests disrupted sleep impairs consolidation of extinction, though no studies have examined this experimentally using total sleep deprivation.

Methods

Seventy-one healthy controls underwent a paradigm to acquire conditioned fear to a visual cue. Twenty-four hours after fear conditioning, participants underwent extinction learning. Twenty-four hours after extinction learning, participants underwent extinction recall. Participants were randomized to three groups: 1) well-rested throughout testing ("normal sleep"; n = 21); 2) 36 hours

SUBMITTER: Straus LD 

PROVIDER: S-EPMC5526630 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature