30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses.

ABSTRACT:

Purpose

MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone.

Methods

Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with preparation pulses to selectively image bound or pore water. The 2D methods were quantitatively compared with previously implemented 3D methods in the tibia in five volunteers.

Results

The mean difference between bound and pore water concentration acquired from 3D and 2D sequences was 0.6 and

SUBMITTER: Manhard MK 

PROVIDER: S-EPMC5526671 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature