Kidney Injury and Repair Biomarkers in Marathon Runners.

ABSTRACT:

Background

Investigation into strenuous activity and kidney function has gained interest given increasing marathon participation.

Study design

Prospective observational study.

Setting & participants

Runners participating in the 2015 Hartford Marathon.

Predictor

Completing a marathon.

Outcomes

Acute kidney injury (AKI) as defined by AKI Network (AKIN) criteria. Stage 1 AKI was defined as 1.5- to 2-fold or 0.3-mg/dL increase in serum creatinine level within 48 hours of day 0 and stage 2 was defined as a more than 2- to 3-fold increase in creatinine level. Microscopy score was defined by the number of granular casts and renal tubular epithelial cells.

Measurements

Samples were collected 24 hours premarathon (day 0), immediately postmarathon (day 1),

SUBMITTER: Mansour SG 

PROVIDER: S-EPMC5526736 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature