Management of inflammatory bowel disease with Clostridium difficile infection.

ABSTRACT:

Aim

To address the management of Clostridium difficile (C. difficile) infection (CDI) in the setting of suspected inflammatory bowel disease (IBD)-flare.

Methods

A systematic search of the Ovid MEDLINE and EMBASE databases by independent reviewers identified 70 articles including a total of 932141 IBD patients or IBD-related hospitalizations.

Results

In those with IBD, CDI is associated with increased morbidity, including subsequent escalation in IBD medical therapy, urgent colectomy and increased hospitalization, as well as excess mortality. Vancomycin-containing regimens are effective first-line therapies for CDI in IBD inpatients. No prospective data exists with regards to the safety or efficacy of initiating or maintaining corticosteroid, immunomodul

SUBMITTER: D'Aoust J 

PROVIDER: S-EPMC5526769 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature