Project description:Key clinical messageFrom a literature review, this is the first case of fetal 16p12.2 microdeletion syndrome inherited from a normal father with autopsy description and evidence of spongious cardiomyopathy. First trimester intake of doxycycline could be a cofactor.AbstractPrenatal diagnosis of a 16p12.2 microdeletion, inherited from normal father, is reported in a dysmorphic 20 weeks fetus. Histopathological examination of the myocardium (not present in the 65 cases in literature) showed bifid apex of the heart and spongiotic structure. Correlation between the deleted genes and cardiomyopathy is discussed.

| S-EPMC10315447 | biostudies-literature

Cardiac Hydatid Cyst in a 34-Year-Old Ethiopian Woman With Heart Failure.

Project description:Although the majority of hydatid cysts are found in the liver and lungs, cardiac hydatid cysts, particularly those in the left ventricle and interventricular septum, pose unique challenges because of their extremely rare manifestation of cystic echinococcosis, critical location, and potential for serious complications. Although uncommon, a hydatic cyst of the heart should be investigated in a patient with an intracardiac mass-particularly if it is cystic-and in a patient with symptoms of heart failure caused by a mass shown in imaging examinations. We present a case of left ventricular hydatid cyst in a 34-year-old woman who had been complaining of worsening dyspnea, shortness of breath, orthopnea, and cough for 3 weeks.

| S-EPMC11911885 | biostudies-literature

Intermittent complete atrioventricular block in a 20-year-old woman with cardiac sarcoidosis: a case report.

Project description:BackgroundAtrioventricular conduction disturbance may rarely be caused by cardiac involvement of sarcoidosis.Case summaryA 20-year-old Caucasian female with exertional dyspnoea was admitted to the hospital. Electrocardiogram revealed intermittent complete atrioventricular block with ventricular escape rhythm. Laboratory findings indicated no obvious cause for the complete heart block, and echocardiography showed no abnormalities with normal systolic left ventricular function. However, in gadolinium-enhanced cardiovascular magnetic resonance imaging, a mass at the basal septum with high intensity of T2-weighted signal was found, and 18-fluorodeoxyglucose positron emission tomography revealed severe enhancement in this area and in the mediastinal lymph nodes. The diagnosis of cardiac sarcoidosis was established by the detection of non-caseating epithelioid granulomas in the endobronchial lymph node biopsy. Corticosteroid therapy with oral administration of 30 mg prednisolone was initiated, and complete recovery of atrioventricular block was observed within several weeks, obviating the need for permanent pacemaker implantation.DiscussionCardiac sarcoidosis can cause complete atrioventricular block and should always be considered, especially in younger patients. Early diagnosis and initiation of corticosteroid therapy may lead to complete recovery of conduction system without the need for permanent pacemaker implantation.

| S-EPMC9753548 | biostudies-literature

Diffuse atrophic papules and plaques, intermittent abdominal pain, paresthesias, and cardiac abnormalities in a 55-year-old woman.

Project description:KEY TEACHING POINTS.

| S-EPMC5112129 | biostudies-literature

A 67-year-old woman with knee pain.

Project description: Not available

| S-EPMC4234716 | biostudies-literature

Case 6: A 27-Year-Old Woman With Dysarthria.

Project description: Not available

| S-EPMC9829511 | biostudies-literature

A 68-year-old woman with sleep-onset insomnia.

Project description: Not available

| S-EPMC3832560 | biostudies-literature

An 82-Year old woman with a palpable lymph node

Project description:An 82-year-old woman with a history of LD stage SCLC of her left upper lobe nine years earlier, had been treated with five cycles chemotherapy cyclophosphamide, doxorubicin and etoposide (CDE)) resulting in a complete response. She received prophylactic cranial irradiation. Now she presented with a palpable mass in the right supra-clavicular fossa. Her further medical history revealed coronary vascular disease, for which she underwent PTCA; mild aortic valve stenosis and a pacemaker to treat a third degree AV block. She has NYHA class II. She had a history of cigarette smoking but she stopped when SCLC was diagnosed nine years ago. She had no dyspnea

2010-06-12 | GSE16575 | GEO

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