TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H₂S System.

ABSTRACT: Ten-eleven translocation-2 (TET2) protein is a DNA demethylase that regulates gene expression through DNA demethylation and also plays important roles in various diseases including atherosclerosis. Endothelial dysfunction represents an early key event in atherosclerotic disease. The cystathionine-γ-lyase (CSE)/hydrogen sulfide (H₂S) is a key endogenous system with protective effects on endothelial functions. In this study, we examined how TET2 regulates oxidized low-density lipoprotein (oxLDL)-induced dysfunction of human umbilical vein endothelial cells (HUVECs) and determined the role of the CSE/H₂S system. Treatment with oxLDL resulted in downregulation of both TET2 expression and CSE/H₂S system in HUVECs. TET2 was found to have protective effects on oxL

SUBMITTER: Peng J 

PROVIDER: S-EPMC5526911 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature