Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development.

ABSTRACT: Although transcript levels have been traditionally used as a surrogate measure of gene expression, it is increasingly recognized that the latter is extensively and dynamically modulated at the level of translation (messenger RNA to protein). Over the recent years, significant progress has been made in dissecting the complex posttranscriptional mechanisms that regulate gene expression. This advancement in knowledge came hand in hand with the progress made in the methodologies to study translation both at gene-specific as well as global genomic level. The majority of translational control is exerted at the level of initiation; nonetheless, protein synthesis can be modulated at the level of translation elongation, termination, and recycling. Sequence and structural elements and epitranscripto

SUBMITTER: Vaklavas C 

PROVIDER: S-EPMC5526920 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature