Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.

ABSTRACT: Cell competition is a form of cell interaction that causes the elimination of less fit cells, or losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can cause cells to become losers; however, it is not known how. Here we show that Drosophila wing disc cells carrying functionally unrelated loser mutations (Minute and mahjong) display the common activation of multiple stress signalling pathways before cell competition and find that these pathways collectively account for the loser status. We find that JNK signalling inhibits the growth of losers, while JAK/STAT signalling promotes competition-induced winner cell proliferation. Furthermore, we show that losers display oxidative stress response activation and, strikingly, that activation of this pathway alone,

SUBMITTER: Kucinski I 

PROVIDER: S-EPMC5526992 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature