Lactate provides a strong pH-independent ventilatory signal in the facultative air-breathing teleost Pangasianodon hypophthalmus.

ABSTRACT: Fish regulate ventilation primarily by sensing O₂-levels in the water and arterial blood. It is well established that this sensory process involves several steps, but the underlying mechanisms remain frustratingly elusive. Here we examine the effect of increasing lactate ions at constant pH on ventilation in a teleost; specifically the facultative air-breathing catfish Pangasianodon hypophthalmus. At lactate levels within the physiological range obtained by Na-Lactate injections (3.5 ± 0.8 to 10.9 ± 0.7 mmol L^-1), gill ventilation increased in a dose-dependent manner to levels comparable to those elicited by NaCN injections (2.0 µmol kg^-1), which induces a hypoxic response and higher than those observed in any level of ambient hypoxia (lowest PO₂

SUBMITTER: Thomsen MT 

PROVIDER: S-EPMC5527003 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature