Thy-1⁺ Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis.

ABSTRACT: Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1 (CD90) marks CAFs that promote tumor cell invasion in a murine model of Kras^G12D-driven lung adenocarcinoma (Kras^LA1), here we postulated that human lung adenocarcinomas containing Thy-1⁺ CAFs have a worse prognosis. We first examined the location of Thy-1⁺ CAFs within human lung adenocarcinomas. Cells that co-express Thy-1 and α-smooth muscle actin (αSMA), a CAF marker, were located on the tumor periphery surrounding collectively invading tumor cells and in perivascular regions. To

SUBMITTER: Schliekelman MJ 

PROVIDER: S-EPMC5527099 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature