Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

ABSTRACT: COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

SUBMITTER: Barnych B 

PROVIDER: S-EPMC5527127 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature