Genetic variants in the peripheral auditory system significantly affect adult cochlear implant performance.

ABSTRACT:

Background

Cochlear implantation is an effective habilitation modality for adults with significant hearing loss. However, post-implant performance is variable. A portion of this variance in outcome can be attributed to clinical factors. Recent physiological studies suggest that the health of the spiral ganglion also impacts post-operative cochlear implant outcomes. The goal of this study was to determine whether genetic factors affecting spiral ganglion neurons may be associated with cochlear implant performance.

Methods

Adults with post-lingual deafness who underwent cochlear implantation at the University of Iowa were studied. Pre-implantation evaluation included comprehensive genetic testing for genetic diagnosis. A novel score of genetic variants affecting genes with fun

SUBMITTER: Shearer AE 

PROVIDER: S-EPMC5527292 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature