FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach.

ABSTRACT: The development of novel targeted therapies for cancer treatment requires identification of reliable targets. FAM83 ('family with sequence similarity 83') family members A, B, and D were shown recently to have oncogenic potential. However, the overall oncogenic abilities of FAM83 family genes remain largely unknown. Here, we used a systematic and integrative genomics approach to investigate oncogenic properties of the entire FAM83 family members. We assessed transcriptional expression patterns of eight FAM83 family genes (FAM83A-H) across tumor types, the relationship between their expression and changes in DNA copy number, and the association with patient survival. By comparing the gene expression levels of FAM83 family members in cancers from 17 different tumor types with those in their

SUBMITTER: Snijders AM 

PROVIDER: S-EPMC5527452 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature