T-cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer.

ABSTRACT: T-cell immunoglobulin mucin 3 (TIM3) contributes to immune suppression during progression of many cancers, but the precise role of TIM3 in head and neck squamous cell carcinoma (HNSCC) is not clearly understood. In this study, we report that TIM3 expression was significantly up-regulated in patients with HNSCC and associated with lymph node metastasis. Additionally, TIM3 expression was increased in patients with recurrent HNSCC and patients with preradiotherapy or prechemotherapy. We also characterized CD8⁺ T cells and CD11b⁺ CD33⁺ myeloid-derived suppressor cells (MDSCs) in human HNSCC, and found that their expression was positively correlated with TIM3 expression. To determine the underlying mechanism of TIM3 in immune response during HNSCC progression, w

SUBMITTER: Liu JF 

PROVIDER: S-EPMC5527458 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature