Transcription factors down-stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus.

ABSTRACT: Overactivation in Ras signaling has been under intensive study as the molecular basis for development of cancer. Such overactivation can occur in the presence or absence of mutations in Ras gene resulting in activation of a series of down-stream effectors such as transcription factors. Different studies have shown the activation of Ras down-stream effectors in non-Hodgkin lymphoma (NHL) although mutations in Ras are not prevalent in this malignancy. Since overactivation in Ras signaling also increases permissiveness of cancer cells to infection by oncolytic versions of herpes simplex virus (e.g. R3616), we were interested in evaluating the value of transcription factors down-stream of Ras as molecular indicators for permissiveness to herpes therapy. In order to accomplish this, and also to

SUBMITTER: Esfandyari T 

PROVIDER: S-EPMC5527539 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature